Postdoctoral Fellow - Feixiong Cheng Lab

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Job Title Postdoctoral Fellow - Feixiong Cheng Lab Location Cleveland Facility Cleveland Clinic Main Campus Department

Job Code X1004 Shift Variable Schedule 12:00am-12:00am Job Summary Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through Cleveland Clinic Research. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years. Compensation follows the NIH NRSA Postdoctoral Salary Scale based on total years of postdoctoral experience. Job Details NIH NRSA Postdoctoral Salary Scale Years of Experience: Stipend for FY 2026 0: $63,480 1: $63,900 2: $64,380 3: $66,948 4: $69,180 5: $71,748 6: $74,424 7 or More: $77,076

The Cheng Lab and Cleveland Clinic Genome Center seek highly motivated Postdoctoral Research Fellows for experimental and computational research focused on human complex diseases, particularly Alzheimer's disease and brain health. Fellows will join institutionally and federally funded projects and collaborate with investigators across Cleveland Clinic and Case Western Reserve University. Computational applicants should hold a PhD or MD in bioinformatics, genome science, systems biology, biomedical informatics, computational biology, machine learning, data science, drug discovery, or a related field. Strong computational skills, proficiency in at least one programming language such as R, Python, Perl, C++, or Java, and knowledge of statistics and mathematics are required for computational positions. Proficiency in spoken and written English is required for all candidates. Positions are available immediately. Applications will be considered until December 31, 2026, or until the positions are filled. Please use the email subject line: Postdoc-Application - Your Name

Principal Investigator: Feixiong Cheng, PhD

Cleveland Clinic Research Department: Genome Center, Genomic Sciences and Systems Biology

Lab Research Topics:

• Alzheimer's disease and brain health
• Functional genomics and multi-omics
• Artificial intelligence and computational biology
• Network medicine and systems biology
• Precision medicine and drug discovery

For more information about the lab's research, please visit: https://www.lerner.ccf.org/genomics-research/ or contact William Martin at [email protected]

Responsibilities:

• Conduct experimental or computational research to investigate disease mechanisms and identify diagnostic biomarkers and therapeutic targets.
• Generate or analyze molecular profiling data using functional genomics, transcriptomics, proteomics, metabolomics, or related approaches.
• Apply experimental models or computational methods to integrate molecular findings with large-scale patient data.
• Collaborate with physicians, geneticists, and computational and experimental biologists on institutionally and federally funded projects.

Education:

• PhD or MD/PhD required
• MD with relevant laboratory experience may substitute for PhD

Languages:

• English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

• Previous experience in a research or academic setting. Graduate student experience meets this requirement.
• Scientific writing experience

Additional Preferred Qualities:

• For experimental candidates, experience with CRISPR, Prime editing, and functional genomics.
• For experimental candidates, experience with patient-derived iPSC neuronal, microglial, or astrocyte models and brain organoids.
• For computational candidates, experience with machine learning, deep learning, foundation models, and high-performance computing.
• Experience analyzing large-scale genomic datasets, including bulk and single-cell or single-nucleus DNA or RNA sequencing.
• Knowledge of genetics, genomics, cell signaling, gene regulatory networks, and protein-protein interaction networks.

Physical Requirements:

• Ability to perform work in a stationary position for extended periods
• Ability to operate a computer and other office equipment
• Ability to communicate and exchange accurate information
• Ability to distinguish color
• Manual dexterity to handle specimens and repair equipment
• Ability to lift and transport equipment or specimens weighing up to 20 pounds
• May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

• PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

• Cover letter describing research experience and skills.
• Research statement and plan, 2 to 3 pages.
• Curriculum vitae.
• Contact information for three references.

All application materials should be submitted directly via email to William Martin at [email protected]

Keywords: Postdoc, CRISPRi, Prime Editing, iPSC, Brain Organoids,TOPMed, TCGA, ICGC, GTEx, 1000 Genomes, UK Biobank, ENCODE, ExAC, PDB, radiomics, interactomics, electronic health records

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