Histology Technician

Science is an early stage company developing technologies for a range of serious unmet medical needs. We are unafraid to take difficult technical risks, secure in the knowledge that with a clear understanding of what we are doing and with support from powerful modern tools, more progress is possible than might be immediately obvious. Regardless of role or team, the two most important factors we look for in a candidate are evidence of exceptional ability and the addition of positive energy to the group. As a small, very early stage team in a largely unstructured environment, the ability to independently orient yourself to the problems that need to be solved and then follow through is essential. We are seeking a motivated Histology Technician to join our team. The successful candidate will be responsible for executing a range of histological processes on a variety of tissue samples, to support our research teams. Successful candidates are already experts at tissue processing and staining techniques and are familiar with histology best practices and automation tools. Role responsibilities:

• Process biological specimens including cells, organoids and whole tissues from a range of experimental systems through fixation, embedding, and sectioning (paraffin and frozen)
• Operate cryostats and microtomes to cut thin sections of tissue
• Perform both standard histology stains (H&E, trichrome, PAS, etc.) and help develop custom workflows
• Run IHC and IF stainings on sections and whole-mount structures including antibody optimization and multiplexed panels
• Image sectioned and whole mount tissue using slide scanners
• Help maintain the histology laboratory, ensuring a clean and organized workspace
• Follow standard operating procedures and communicate with researchers
• Maintain an extensive biobank with rigorous sample and slide tracking

Key qualifications:

• Expert at histological sectioning (paraffin and cryo) and a track record of clean, consistent sections
• Able to handle a range of small, delicate or otherwise difficult tissues across different model organisms
• Expert at using microtomes
• Expertise at a range of standard histology techniques including but not limited to immunofluorescence and H&E
• Strong proficiency with IHC and/or IF, including antibody optimization and the judgment to distinguish real signal from artifact
• Experience with microscopy and slide scanners
• Strong attention to detail and ability to follow protocols
• Good organizational skills and the ability to keep accurate records
• Strong communication and teamwork skills

Preferred qualifications:

• Highly skilled at specialized microscopic imaging techniques (z-stacking, tiles, stitching)
• Advanced proficiency in biological imaging (bright-field, epi-fluorescence and confocal)
• Bachelor's degree in biology, biochemistry, or a related field
• Histopathology certification
• Experience performing necropsy and transcardial perfusions
• Experience with microscopy

Salary/Pay Range: For individuals hired to work in California, Science is required by law to include a reasonable estimate of the compensation range for this role. We determine your level based on your interview performance and make an offer based on geo-located salary bands. The base salary range for this full-time position is $21-$35 per hour + equity + benefits. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training. Please keep in mind that the equity portion of the offer is not included in these numbers. Benefits: At Science, our benefits are in place to support the whole you:

• Competitive salary and equity
• Medical, dental, vision and life insurance
• Flexible vacation and company-paid holidays
• Healthy meals and snacks provided for non-remote employees
• Paid parental, jury duty, bereavement, family care and medical leave
• Dependent Care Flexible Spending Account, subsidized by Science
• Flexible Spending Account
• 401(k)

Science Corporation is an equal opportunity employer. We strive to create a supportive and inclusive workplace where contributions are valued and celebrated, and our employees thrive by being themselves and are inspired to do their best work.

We seek applicants of all backgrounds and identities, across race, color, ethnicity, national origin or ancestry, citizenship, religion, sex, sexual orientation, gender identity or expression, veteran status, marital status, pregnancy or parental status, or disability. Applicants will not be discriminated against based on these or other protected categories or social identities. Science will also consider for employment qualified applicants with criminal histories in a manner consistent with applicable federal, state and local laws.