Director, Program Management

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Position Overview:

We’re looking for an outstanding program manager with experience advancing early discovery programs through IND approval. This leader will refine and reinforce our program management methodology and lead program management in our early research teams. This role reports to the Vice President, Programs and Strategy.

Responsibilities:

As a Program Manager:

• Working in partnership with research team leadership to develop and guide program strategy, set program goals and facilitate team decision making for the program

• Lead a range of program management activities across programs, including development of project plans, timeline and milestones tracking, team meeting management/minutes, and decision-making support

• Efficiently and collaboratively drive execution of program strategy and the integrated development plan with a sense of urgency

• Proactively identify risks, gaps, and resource bottlenecks; and develop and implement mitigation plans

• Develop and manage the program budget, and long-range plan, including scenario planning as needed, monitor program financials and resourcing plans

• Facilitate strong cross-functional communication by building strong working relationships across the organization

• Develop materials and present program updates/progress at internal company meetings

Enhancing the Program Management function:

• Responsible for the management and communication of Prime’s discovery-stage program plans

• Facilitate cross-functional communication, including input to Leadership Team on program progress

• Support strategic scenario planning discussions, develop risk/mitigation plans, and drive key program decisions through our governance forums

• Reinforce high standards and high performing teams to advance our science

• Support strategic & tactical program planning in partnership with Finance and Strategy/ Portfolio Management, to inform the long-range planning process, detailed investment planning, and portfolio prioritization exercises

• Ensure cross-functional and cross-program sharing of key learnings, and drive change management as applicable

Qualifications:

• Direct experience in program management/program leadership for discovery through early clinical development programs; 6+ years in industry with 3+ years managing programs

• Bachelor’s degree in relevant scientific area required, additional business training or education strongly desired; genetic medicines experience highly desired

• Excellent verbal and written communication skills and strong interpersonal skills to manage relationships, set expectations, facilitate dialogue, and resolve conflict

• Proficient in prioritizing and driving complex programs to milestone completion

• Demonstrated proficiency in program management tools and methodology. Willingness to constantly improve PM tools, implement best practices, and foster change management

• Strategic and financial acumen with the ability to develop and manage program plans, budgets, and timelines.

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range $219,000—$232,000 USD

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.