Synthetic Chemist

Let’s build the future of medicine - together.

Boulder, CO | Full-Time | $125,000–$135,000

YOUR ROLE

As a Synthetic Chemist (Scientist I) at Enveda, you'll build Enveda's library of synthetic authentic standards: human metabolites made quickly and at scale, so our mass spec platform can confirm what it finds. You'll partner with analytical chemists, data scientists, and our Sample Management and Lab Automation teams to turn computationally predicted structures into confirmed compounds. In your first year, you'll stand up our high-throughput synthesis workflow and deliver 250,000 confirmed authentic standards across multiple compound classes. This is a high impact opportunity where you'll influence our mass spec platform and Enveda's compound collection strategy while collaborating with some of the brightest minds in the industry.

WHAT YOU'LL DO

• Own and design syntheses for our authentic standard library, from target list to confirmed compound, including efficient routes to structurally diverse natural metabolites and underexplored compound classes, designed so each compound can be confidently confirmed by LC-MS

• Develop and scale parallel or mixture synthesis workflows that enable rapid production of metabolite authentic standards for analytical validation

• Build the infrastructure and processes to maximize compound production, partnering with our Sample Management and Lab Automation teams on high-throughput experimentation and automation

• Translate computationally predicted molecular structures into confirmed, fully characterized compounds, closing the loop between data science and wet-lab chemistry, fast enough that synthesis is never the bottleneck

• Establish best practices for synthesis prioritization, route scouting, and library design so the team can move quickly through large numbers of targets

• Work in tight feedback loops with analytical chemists and data scientists who are predicting novel metabolite structures from mass spectrometry data at scale

• Support the metabolomics teams who rely on synthetic standards to validate discoveries, and the drug discovery teams who build on the metabolites your standards help confirm

• Help shape Enveda's compound collection strategy, deciding which regions of chemical space to explore next and how to build a library with lasting scientific value

WHAT WE'RE LOOKING FOR

• A PhD in synthetic organic chemistry with 2+ years of hands-on experience in small molecule synthesis design, execution, and analysis

• Someone energized by variety: comfortable pivoting between compound classes, adapting routes on the fly, and working across dozens of distinct scaffolds rather than a single total synthesis campaign

• A chemist who genuinely enjoys working at the boundary of computation and synthesis, and who sees data-driven target selection as an opportunity rather than a constraint

• Hands-on experience running library, parallel, or high-throughput synthesis at the bench (you ran the plates, not only designed them), with a track record of delivering compounds on a timeline

• Comfortable using LC-MS to interpret complex mixtures, not just to monitor reactions

• Out-of-the-box thinking, the ability to envision and build capabilities, and the ability to work effectively within a multi-disciplinary team

• Experience with high-throughput experimentation (HTE) and automation platforms is a plus

• Someone who enjoys challenging problems, thinking big, and stretching the bounds of what's possible

We hire for trajectory, not just credentials. If you meet most of the above and care deeply about this problem, we want to hear from you.

ABOUT ENVEDA

We're a clinical-stage, AI-enabled biotech discovering medicines from nature four times faster than the industry standard. We recently raised $311M in a Series E, bringing total funding to over $845M, and doubled our valuation to $2B. We now have three oral medicines in the clinic, including our lead drug, ENV-294, in Phase 2 trials for eczema and asthma. Forbes named us one of America's Best Startup Employers, and Newsweek recognized us as a Top 100 Most Loved Workplace. We're still early, and most of the best work is ahead of us.

Benefits (Starting Day 1): Medical, dental, and vision covered at 90%, 401(k) with company match, flexible PTO and a company-wide weeklong recharge break, adoption assistance

Our Process: We move fast and respect your time. Typically: a recruiter screen → hiring manager conversation → work sample, technical interview, & culture interview.

Our Values: Curiosity | Agency | Journey | Charity | Unity

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Enveda is protecting Job Seekers

We care deeply about creating a safe, respectful experience for every applicant, so we wanted to share a few guidelines to help you spot anything that doesn’t feel right.

• You’ll always meet real Enveda team members through video or in-person conversations before receiving an offer.

• All communication from us will come from an @enveda.com or @envedabio.com email address.

• We’ll never ask you to purchase equipment, send money, or share sensitive banking details as part of any step in our recruiting process.

If something feels off or you’re unsure whether a message is truly from Enveda, please reach out at anytime at [email protected].

At Enveda, we’re building a place where everyone can do the best work of their life. We are an equal opportunity employer and value diversity in all its forms. Apply now and join a team committed to shaping the future of drug discovery.