Scientist/Senior Scientist, Immunology

About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position NewLimit is seeking a highly motivated Scientist/Senior Scientist in Immunology to lead and execute key discovery-to-preclinical research efforts in inflammatory and autoimmune diseases, with a strong emphasis on T cell and regulatory T cell (Treg) biology. This role will design and implement in vitro screening assays to support lead selection and contribute to preclinical efficacy, safety, and mechanism-of-action studies. You will work closely with cross-functional partners to support program advancement toward IND-enabling studies.

What you'll do In your role as a Scientist, you will:

• Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and evaluate epigenetic reprogramming interventions for aged T cells, including integration and interpretation of complex, multi-modal datasets

• Develop scalable functional assays in T cells and Tregs to predict therapeutic activity and inform lead selection

• Design and lead in vivo and in vitro immunology studies to support target discovery, validation, and preclinical development

• Contribute deep expertise in inflammatory and autoimmune disease biology to experimental design and data-driven program strategy

• Drive research in Treg biology, including differentiation, stability, and suppressive function

• Author or contribute to study reports, internal data packages, and regulatory-supporting documentation

• Mentor junior scientists and foster a collaborative, rigorous scientific culture

• Present data, analyses, and scientific recommendations clearly to internal teams and leadership Requirements

• Ph.D. in immunology, cell biology, or a related field or BS/MS with 6+ years of relevant industry experience

• Hands-on experience with multi-parameter flow cytometry

• Experience designing in vivo models of autoimmune or inflammatory disease

• Experience with primary immune cell isolation, ex vivo culture, and Treg functional assay Nice to have

• Experience with pooled in vitro or in vivo screening approaches using bulk or single-cell readouts (e.g., CRISPR fitness screens, Perturb-seq, CROP-seq)

• Experience with rheumatoid arthritis and/or colitis models

• Experience authoring IND-supporting study reports

• Experience managing or partnering with CROs to support preclinical studies, including alignment on study design, timelines, and data quality

• Familiarity with basic computational tools for data analysis (e.g., Python, R) Benefits NewLimit offers generous benefits to ensure our team can focus on our mission:

• Health, dental, and vision insurance

• 401(k) with company match

• Paid parental leave

• Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays

• Meals and snacks on-site

Salary Range: $130,000 to $180,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.