Technical Development Principal Scientist, Mass Spectrometry Characterization Lead

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech!

Join our global Analytical Development and Quality Control team as a Technical Development Principal Scientist, Mass Spectrometry Characterization Lead , driving analytical strategies that transform cutting-edge biologic therapeutics from early development to commercialization. In this role, you will bridge strategic leadership with hands-on laboratory expertise within a collaborative, multidisciplinary environment dedicated to delivering life-changing medicines. You will lead mass spectrometry characterization, solve complex analytical challenges, and guide cross-functional teams with scientific excellence and impact.

The Opportunity

• Lead the mass spectrometry (MS) characterization strategy and execution across all stages of biologic therapeutic development, from early development through to commercial launch.

• Design, execute, and interpret complex liquid chromatography-mass spectrometry (LC-MS) analyses to establish deep structural understanding of protein modalities and resolve technical root causes.

• Develop and implement phase-appropriate MS methods and advanced multi-attribute method (MAM) strategies where standard analytical assays fall short.

• Identify, monitor, and quantify critical quality attributes (CQAs) and post-translational modifications (PTMs) to ensure reliable analytical control.

• Support process development milestones, including cell line selection, purification, formulation, stability, minor variant characterization, and structure-function elucidation.

• Author filing-ready MS characterization sections for global regulatory submissions (IND, BLA, and MAA) and represent technical packages in regulatory interactions.

• Collaborate closely with multidisciplinary teams, analytical leads, and external research/manufacturing partners to achieve project delivery milestones.

• Mentor scientific team members in MS data interpretation and champion modern analytical capabilities and best practices.

Who you are

• You hold a Ph.D. with 4–6+ years of relevant experience, or an M.S./B.S. with 6–10+ years of experience in Analytical Chemistry, Biochemistry, Chemical Engineering, or a related field.

• You bring deep analytical expertise in liquid chromatography-mass spectrometry (LC-MS) applied to the characterization of proteins or related therapeutic modalities.

• You possess strong working knowledge of chemistry, manufacturing, and controls (CMC) drug development and regulatory filing processes (IND/BLA).

• You demonstrate excellent collaborative, organizational, and communication skills, thriving both as an independent lead and as part of a dynamic, multidisciplinary team.

• You are an agile problem-solver motivated by scientific curiosity, technical quality, and delivering meaningful results in a fast-paced environment.

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 - $224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits (https://roche.ehr.com/default.ashx?CLASSNAME=splash)

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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