Postdoctoral Fellow-MSH-32035-054

Job Description

Salary: Commensurate with experience, in accordance with NIH and Icahn School of Medicine at Mount Sinai guidelines.

Department: Diabetes, Obesity and Metabolism Institute (DOMI)

Physical work location: (must be proper street address) 1428 Madison Ave, Atran building 5 th floor

Name PI or Supervisor: (include phone and email) Liora Katz, [email protected]

Web link to Lab: https://profiles.icahn.mssm.edu/liora-s-katz

Web link to Department:

Administrative Contact: Jessica Correa- [email protected]

Qualifications

Educational and other Requirements for the position:

Ph.D., M.D./Ph.D., or equivalent degree in Molecular Biology, Biochemistry, Biomedical Sciences, or a closely related discipline.

Experience Required:

Candidates must possess a strong, demonstrable background in molecular biology and biochemistry. Mandatory hands-on experience in mouse handling and in vivo protocols is required. Prior expertise in pancreatic islet biology is highly preferred.

Goals/Outcomes of the Research Project:

To elucidate the pathways mediating beta-cell failure and validate therapeutic interventions utilizing molecular glues to preserve beta-cell mass and function. The fellow will be expected to drive the project toward high-impact peer-reviewed publications, present research at national/international conferences (such as the ADA Scientific Sessions or HIRN meetings), and contribute to grant applications.

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 021 - Metabolism Institute - ISM, Icahn School of Medicine

Responsibilities

Details of Research Project:

The laboratory investigates pancreatic beta-cell biology, focusing on the mechanisms of beta-cell failure, adaptive expansion, and stress resilience in metabolic disease. Supported by multiple active NIH R01 and R03 grants, this project specifically evaluates transcription factor dynamics, including the ChREBP axis, and cytoprotective mechanisms. The incoming postdoctoral fellow will lead efforts to study early drivers of beta-cell failure and evaluate novel therapeutic small-molecule 14-3-3 molecular glues (such as Compound 43) designed to shield beta-cells from glucolipotoxicity and cytokine stress.

Technical Duties: Mandatory hands-on mouse handling

Core molecular biology and biochemistry protocols.

Confocal Imaging

NGS sequencing and analysis (optional)

About Us

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

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About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.