Development Asset Leader, Liver Franchise

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Prime Medicine is a clinical-stage biotechnology company pioneering Prime Editing, a novel and precise "search-and-replace" gene editing technology capable of correcting the vast majority of disease-causing genetic mutations. Our approach allows us to make virtually any type of genetic edit — insertions, deletions, and all base-to-base conversions — without introducing double-strand breaks or requiring a separate donor DNA template. We are advancing a broad pipeline of Prime Editing–based therapies, including in vivo liver-directed programs and ex vivo approaches for ultra-rare disease, with a mission to develop one-time, curative genetic therapies for patients with limited or no treatment options today.

Position Overview

Location: Cambridge, MA (hybrid — min. 3-days a week onsite)

Reports to: VP, Programs and Strategy

Level: VP

Prime Medicine is seeking an experienced, strategic, and operationally rigorous Development Asset Leader to assume leadership of our in vivo LNP-delivered liver programs as they advance from early clinical development through licensure, beginning with our Wilson's Disease and Alpha-1 Antitrypsin Deficiency programs.

The Asset Leader will step in seamlessly once a liver program has cleared IND and owns the asset through clinical PoC and regulatory approval/licensure. As Prime's liver portfolio grows, this leader is expected to scale from single-asset ownership into a franchise-level leadership capability, building the processes, governance, and team structure to efficiently deploy our capital to advance multiple concurrent clinical assets.

The ideal candidate is equally comfortable engaging with both internal (executive management and Board) and external (regulatory authorities, KOLs, CRO/CDMO leadership) stakeholders as they are running a cohesive cross-functional team, building genuine esprit de corps across a lean organization while holding the asset accountable to timeline, budget, and scientific rigor.

Primary Responsibilities

• Own the Integrated Development Plan for liver assets from IND acceptance through regulatory approval/licensure, including trial design input, data package strategy, and key go/no-go decision points

• Anticipate, frame, and escalate the critical considerations that materially change the asset's risk/value profile to executive management

• Lead a matrixed team spanning Clinical, Regulatory, CMC/Manufacturing, Biostatistics, Pharmacovigilance, Med Affairs/Patient Advocacy, and Commercial

• Deploy, where appropriate, AI-enabled project management tooling (timelines, risk registers, cross-functional dashboarding)

• As the liver franchise expands, help design the team structure, governance cadence, and knowledge-transfer processes to advance Prime’s portfolio

• Serve as a key point of contact with CROs/CDMOs, KOLs, and patient advocacy groups for the asset, and represent the asset in regulatory interactions alongside Regulatory Affairs

Preferred Qualifications

• Advanced degree in life sciences, medicine, or related field (PhD, MD, PharmD) preferred; equivalent industry experience considered

• 12+ years of drug development experience in biotech/pharma, with demonstrated leadership of a clinical-stage asset from IND through late-stage development

• Direct experience in genetic medicines (gene/gene editing therapies, RNA-based therapeutics) or rare disease preferred; liver-directed or LNP delivery experience a strong plus

• Track record of cross-functional program leadership and accountability spanning Clinical, Regulatory, CMC, and Nonclinical

• Demonstrated ability to influence without formal authority, build team culture, and manage external partners (consultants, CROs, KOLs) as an extension of the internal team

• Experience or genuine interest in applying AI tools to project/portfolio management

• Comfort operating in a lean, resource-constrained organization where the Asset Leader is expected to build capability

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range $360,000—$408,000 USD

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.