Senior Manager, Commercial Supply Chain

MISSION

Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously.

POSITION SUMMARY

Mirum Pharmaceuticals is seeking an experienced, highly motivated, and detail-oriented Senior Manager, Commercial Supply Chain to support its growing global commercial portfolio and new product launches. This position will be primarily responsible for managing domestic and international commercial distribution, inventory management, and order-to-cash (O2C) operations to ensure timely, accurate, and compliant product delivery across global markets. In addition, the role will support end-to-end (E2E) commercial supply planning activities, including demand and supply alignment, labeling and packaging coordination, and finished product supply execution, while developing the capabilities to provide effective planning backup and ensure business continuity. The successful candidate will collaborate closely with cross-functional teams and external supply chain partners to drive operational excellence, maintain uninterrupted commercial supply, and support patient access.

JOB FUNCTIONS/RESPONSIBILITIES

• Lead domestic and international commercial distribution operations to ensure timely, accurate, and compliant product delivery across global markets.

• Oversee order-to-cash (O2C) activities, including customer order management, inventory allocation, order fulfillment, shipment execution, and reconciliation in collaboration with Commercial Operations and Finance.

• Manage commercial finished goods inventory across North American 3PLs, ensuring inventory accuracy through regular reconciliation, product availability, timely replenishment, and effective shelf-life management.

• Manage relationships and operational performance of 3PLs, distributors, and logistics partners, including KPI development and monitoring, business reviews, and issue resolution.

• Support new product launches, market expansion, distribution network readiness, supplier qualification, and implementation of new distribution partners

• Collaborate with Quality and other cross-functional teams to ensure distribution compliance and support deviation investigations, change controls, CAPAs, and other quality-related activities, as applicable.

• Drive continuous improvement of distribution, inventory management, and O2C processes through standardized procedures, system enhancements, and operational efficiencies.

• Support E2E commercial supply planning activities, aligning demand, manufacturing, labeling and packaging, inventory, and distribution to ensure product availability.

• Collaborate with CMOs, CPOs, and cross-functional teams to monitor manufacturing and packaging schedules, component availability, finished product readiness, and supply execution.

• Support inventory projections, replenishment planning, supply-demand reconciliation, and proactive identification and mitigation of supply risks.

• Participate in commercial labeling and packaging planning, including packaging readiness, market-specific supply requirements, and new product introductions.

• Develop proficiency in E2E commercial planning processes, systems, and master data to provide effective backup support for supply planning and labeling and packaging activities.

• Support supply chain transitions, business continuity, and continuous improvement initiatives while staying informed of regulatory changes impacting commercial supply planning and distribution.

QUALIFICATIONS

Education /Experience:

• Bachelor’s degree in Supply Chain Management, Business Administration, Operations Management, Logistics, or a related field.

• Minimum of 8 years of progressive experience in commercial supply chain, distribution, logistics, inventory management, or order-to-cash operations within the pharmaceutical or biotechnology industry.

• Demonstrated experience managing domestic and international commercial distribution operations, including third-party logistics (3PL) providers and external distribution partners.

• Strong understanding of order-to-cash processes, including customer order management, order fulfillment, inventory allocation, shipment execution, and reconciliation.

• Working knowledge of pharmaceutical Good Distribution Practices (GDP), Good Manufacturing Practices (GMP), and applicable regulatory and distribution requirements.

• Experience with international logistics, import/export requirements, customs clearance, Incoterms, and temperature-controlled pharmaceutical transportation.

• Experience collaborating with cross-functional teams, including Commercial Operations, Finance, Quality, Regulatory Affairs, and external supply chain partners.

• Demonstrated ability to independently manage complex operations, resolve supply chain issues, and drive process improvements.

• Experience managing contract manufacturing organizations (CMOs), contract packaging organizations (CPOs), and multiple global 3PLs.

• Knowledge of end-to-end commercial supply planning, including demand and supply planning, inventory projections, and supply-demand reconciliation.

• Experience supporting global pharmaceutical product launches and commercial supply chain expansion.

• Experience with advanced supply planning systems, such as Kinaxis RapidResponse, is preferred.

• ASCM CPIM certification is preferred.

• Demonstrated project management and negotiation skills, with experience supporting new product supply chain planning preferred.

• Familiarity with pharmaceutical serialization, track-and-trace, and market-specific distribution requirements.

• Experience establishing operational KPIs, conducting external partner business reviews, and leading continuous improvement initiatives.

Knowledge, Skills and Abilities:

• Strong organizational and time management skills, with exceptional attention to detail and the ability to manage multiple priorities and meet tight deadlines in a fast-paced environment.

• Excellent analytical, problem-solving, and decision-making skills, with the ability to proactively identify supply chain risks, resolve complex operational issues, and implement effective solutions.

• Strong communication, interpersonal, and cross-functional collaboration skills, with demonstrated ability to manage external partners and influence stakeholders without direct reporting authority.

• Demonstrated ability to work independently, take ownership of operational deliverables, and drive continuous improvement across commercial supply chain processes.

• Solid understanding of end-to-end commercial supply chain processes and the interdependencies between demand and supply planning, manufacturing, labeling and packaging, inventory management, and distribution.

• Ability and willingness to develop broader E2E commercial supply planning expertise, including systems and processes, to provide effective operational backup and ensure business continuity.

• Demonstrated integrity, accountability, adaptability, and a proactive, hands-on, team-oriented approach, with the ability to thrive in a small, dynamic organization.

The salary range for this position is $180,000 to $190,000 USD. Compensation will be determined based on several factors including, but not limited to; skill set, years of experience, and the employee’s geographic location. Please note that the required compensation details listed in US role postings reflect the base salary only, and do not include bonus, equity, or benefits unless otherwise provided.

#LI-HYBRID Mirum Pharmaceuticals is committed to Equal Employment Opportunity (EEO) and to compliance with all Federal, State and Local laws that prohibit employment discrimination on the basis of race, age, national origin, ethnicity, religion, gender, gender identity, pregnancy, marital status, sexual orientation, citizenship, genetic disposition or characteristics, disability, veteran’s status or any other classification protected by applicable State/Federal/Local laws.

Mirum Pharmaceuticals provides reasonable accommodation for qualified individuals with disabilities and disabled veterans in job application procedures.