Senior Manager/Director/SME Drug Development

Boston, MA (preferred), San Francisco Bay, Remote About Vibe Bio Vibe Bio empowers biotech and pharma to identify & evaluate assets and indications to make smarter business development and portfolio decisions, faster. The Boston-based AI platform and venture fund enables leaders to generate strategic insights from sophisticated drug development reasoning applied to large sets of interdisciplinary data. Teams can make decisions eight times faster, reduce subject matter expert workload by 75%, and identify 50% more opportunities. Multiple leading biopharma companies rely on Vibe Bio to realize their mission of bringing novel medicines to patients with high unmet medical need. Description Vibe Bio is seeking a Senior Manager or Director-level Subject Matter Expert to join our Delivery team and lead client engagements at the intersection of clinical drug development and AI-enabled decision support. This individual will serve as the engagement lead, owning client delivery end-to-end while translating clinical and scientific questions into clear execution plans and AI-driven deliverables. The role is highly hands-on and requires close collaboration with Vibe’s internal engineering team to develop, test, and refine AI models, workflows and prompts that drive high-quality, defensible outputs for clients. This individual will be working at the intersection of important pharma decisions, generative AI, and product development and operate within an established Delivery function, with operational and project support, and will report directly to the Head of Delivery. What You’ll Do (but is not limited to)

• Lead client engagements as a primary engagement lead within the Delivery team
• Translate client clinical and drug development questions into structured execution and analysis plans suitable for AI-enabled workflows
• Collaborate closely with engineering and data teams to design and refine Vibe’s AI, VibeOne.
• Validate and quality-control AI outputs for clinical relevance and decision readiness
• Lead client meetings and present insights clearly to support decision-making
• Partner with Delivery operations and project support resources to ensure smooth execution
• Contribute to internal best practices and reusable delivery frameworks
• Support light product development by identifying recurring client needs

Your Qualifications

• Advanced degree in a life sciences or clinical discipline (Masters, PhD, PharmD, MD, or equivalent)
• Strong background in clinical and drug development
• Prior CRO experience preferred; AI-enabled CRO or platform experience highly desirable
• Hands-on experience with LLMs, ML models, or AI decision-support tools
• Experience with prompt engineering, iteration, and AI output validation/QC
• Strong collaboration skills with engineering and technical teams
• Startup or fast-paced environment experience preferred
• Excellent client-facing communication and delivery leadership skills

How we help you (Benefits) Working at Vibe Bio is a two-way street: we invest in you as much as you invest in us. Here are the employment benefits we provide:

• Competitive salaries and stock options
• Comprehensive benefits for you and your family (low premiums and deductibles!) including medical, dental, and vision
• Flexible hours, time off, and leave policies
• Periodic get-togethers in-person

Equal Opportunity Employment Vibe Bio is an equal opportunity employer and values diversity at our company. We provide equal employment opportunities to all employees and applicants for employment and prohibit discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. To Apply Please complete this form, or if you prefer to apply by email, please send your resume to [email protected].