Mayo Clinic logo

Senior Software Engineer - AI Platform Engineering

Mayo Clinic

Rochester, MN · HybridFull-time$141–205K/yrSeen 1w agoSeen in employer's feed 1w ago

Most applications go out cold — see where you stand first. No sign-up to start.

Watch jobs like this.

Don't just apply. Show up ready.

Olive works from this exact posting.

At a glance

Compensation
$141–205K/yr
Location
Rochester, MNHybrid
Schedule
Full-time
Work Authorization
Not specified

Olive lists jobs from US employers, including remote roles you can work from the United States.

Job overview

Mayo Clinic is hiring a Senior Software Engineer for AI Platform Engineering to build model and agent runtimes across a hybrid-cloud footprint. The role focuses on scalable, secure, governed AI capabilities, including high-performance hosting, multi-tenant infrastructure, production monitoring and evaluation, and operational reliability. The position is hybrid and requires residence within 100 miles of a Mayo Clinic campus for occasional on-site work.

Skills & qualifications

RequiredNice to have

Skills

Scalable Back-End SystemsContainerizationKubernetesLLM LifecycleAutonomous AgentsInference OptimizationRAG ArchitecturesObservabilityLoggingMetricsTracingDistributed EnvironmentsHigh-Level ProgrammingPythonProblem SolvingTime ManagementSoftware Solution DesignModern Application FrameworksSoftware Engineering PracticesCoding StandardsCode ReviewsSource Control ManagementBuild ProcessesSoftware TestingSoftware OperationsAgile Software DevelopmentVerbal CommunicationWritten CommunicationOpen-Source TechnologiesCloud-Based ServicesCloud Software DevelopmentGCPAWSAzureDatabasesAnalyticsBig Data SystemsBusiness Intelligence ProductsDistributed SystemsHealthcare Software Development

Qualifications

Bachelor's in Computer Science/Engineering or Related Field + 5 Years or Associate's in Computer Science/Engineering or Related Field + 7 Years5 Years Software Engineering Experience7 Years Software Engineering ExperienceMaster's in Computer Science/Engineering or Related Field

Benefits

Medical Insurance
Dental Insurance
Vision Insurance
401(k) Match

Full job description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans (https://jobs.mayoclinic.org/benefits/) – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

  • Medical: Multiple plan options.

  • Dental: Delta Dental or reimbursement account for flexible coverage.

  • Vision: Affordable plan with national network.

  • Pre-Tax Savings: HSA and FSAs for eligible expenses.

  • Retirement: Competitive retirement package to secure your future.

Responsibilities

This is a hybrid position and must be located within 100 miles of a Mayo Clinic campus for occasional on-site expectations based on business needs.

As a Senior Software Engineer for AI Platform Engineering , you will bridge the gap between high-scale systems architecture and frontier AI. You will be one of architects and builders of our Model & Agent Runtimes —the specialized engines that govern how models and autonomous agents execute across our hybrid-cloud footprint.

This isn't just about deployment; it’s about a platform-first mindset . You will ensure that AI capabilities are scalable, secure, and governed through world-class AgentOps, LLMOps, and MLOps practices.

What You’ll Do

  • Architect the Future of Runtimes: Design and implement high-performance hosting environments for both specialized models and autonomous agents.

  • Scale Hybrid-Cloud Infrastructure: Build multi-tenant platform capabilities that support seamless agent and model execution across diverse cloud and on-prem environments.

  • Drive Operational Excellence: Implement robust solutions for real-time monitoring, distributed tracing, and automated evaluation of agents & models in production.

  • Operational Stewardship: Act as a member of our rotational platform operational team, ensuring the reliability and uptime of critical AI services.

  • Collaborate & Advocate: Partner with cross-functional AI teams to identify system friction, streamlining their workflows and accelerating the delivery of AI-driven value.

What You’ll Bring

  • Deep Systems Expertise: Proven experience building scalable back-end systems, ideally with a focus on containerization and orchestration (Kubernetes).

  • AI/ML Fluency: Strong understanding of the lifecycle of LLMs and autonomous agents, including inference optimization and RAG architectures.

  • Operational Rigor: A track record of implementing observability (logging, metrics, tracing) in complex, distributed environments.

  • Problem-Solving Mindset: The ability to turn abstract AI research into production-grade, hardened platform features.

Why this team? We are moving beyond simple model serving. We are building the foundational "nervous system" for autonomous agents in a high-stakes environment where performance and governance are non-negotiable.

Qualifications

Required qualifications for this position include: Bachelor's Degree in Computer Science/Engineering or related field with 5 years of experience as noted below; OR an Associate’s degree in Computer/Science/Engineering or related field with 7 years of experience.

Have in-depth knowledge of software engineering with experience coding applications or services in a high-level programming language, preferably Python, and a basic knowledge of related fields. Demonstrated problem solving and time management skills. Possesses strong technical aptitude for designing and implementing software solutions. Experience with modern application development frameworks. Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations. Deep hands-on technical expertise, excellent verbal and written communication skills. Experience with Agile software development techniques.

Preferred qualifications:

  • Master's degree in Computer Science/Engineering or related field.

  • Ability to use a wide variety of open-source technologies and cloud-based services.

  • Experience writing software for the cloud (GCP, AWS, Azure).

  • Experience in databases, analytics, big data systems or business intelligence products.

  • Experience building high-performance, highly available and scalable distributed systems.

  • Experience developing software for healthcare related industries.

Authorization to work and remain in the United States, without necessity for Mayo Clinic sponsorships now, or in the future (for example, be a U.S. Citizen, national, or permanent resident, refugee, or asylee). Mayo Clinic does not participate in the F-1 STEM OPT extension program.

Exemption Status

Exempt

Compensation Detail

$141,024 - $204,526 / year

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

Monday - Fridays; 8:00 AM to 5:00 PM CST. This is a hybrid position and must be located within 100 miles of a Mayo Clinic campus for occasional on-site expectations based on business needs.

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations)

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" (https://www.eeoc.gov/poster) . Mayo Clinic participates in E-Verify (https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf) and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter

Miranda Grabner

Equal opportunity

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.

How this job compares

Set against the 40,760 open Software Engineer jobs on Olive Jobs, counted November 2, 2026.

Pay
  • This posting$141–205K/yr
  • Minnesota median$106–192K/yr518 salary ranges
  • US median$135–217K/yr32,338 salary ranges

This range's midpoint, $173K, is 14% above the Minnesota median midpoint ($151K) — in the middle half of Software Engineer salary ranges in Minnesota.

Openings
Olive Jobs lists 611 open Software Engineer jobs in Minnesota and 40,760 across the US. 7% of them nationwide are listed as remote or flexible.
Hiring the most in Minnesota
Experience
This posting asks for at least 5 years of experience; Software Engineer postings that state a minimum ask for 5 years at the median (33,054 postings).
Education
14,368 of the 40,760 open Software Engineer jobs (35%) ask for a bachelor's degree or higher.

Counted across the open, public US postings on Olive Jobs on November 2, 2026. Pay medians are the middle values of the low ends and of the high ends of postings that list both ends of a range in the same cadence (a yearly salary or an hourly rate); a range's midpoint is halfway between its ends. Pay and experience figures resting on fewer than 20 postings are left out.

You've read the whole posting — now see how you match it.