Senior Scientist, Mass Spectrometry

General Description:

At BeOne Institute, we extend BeOne’s execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:

• Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.

• Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision.

• Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

As a Senior Scientist at BeOne Institute, you will play an important role in advancing cutting-edge research at our San Carlos, CA site. You will apply advanced mass spectrometry technologies to uncover novel biological insights, enable emerging therapeutic modalities, and develop innovative screening and characterization approaches for drug discovery. Working at the interface of biology, chemistry, and technology development, you will collaborate with multidisciplinary teams to address challenging scientific questions, develop new analytical capabilities, and generate insights that can inform future therapeutic opportunities. This is a unique opportunity to pursue bold ideas and translate them into real medicines!

Essential Functions of the Job:

• Contribute creatively to Institute research by generating ideas, challenging assumptions, and advancing innovative scientific projects.

• Design and execute mass spectrometry-based studies to address biological questions, support emerging therapeutic modalities, and enable drug discovery research.

• Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and pathway biology.

• Evaluate and implement new mass spectrometry technologies, workflows, and applications to enhance scientific and technical capabilities.

• Operate, maintain, troubleshoot, and continuously improve mass spectrometry platforms to ensure robust analytical performance and high-quality data generation.

• Analyze, interpret, and communicate mass spectrometry data, translating analytical results into meaningful biological and drug discovery insights.

• Collaborate closely with scientists across biology, chemistry, and related disciplines to develop fit-for-purpose analytical approaches and support multidisciplinary research efforts.

• Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.

Supervisory Responsibilities:

• May be a contact for external CRO partners when needed

• May provide matrix or line-function leadership for project teams when needed

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Computer Skills:

• Proficiency with mass spectrometry data acquisition, processing, and analysis software

• Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets

• Experience with software and tools for MS-based screening and assay development

Required Qualifications:

• Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 2+ years (Ph.D.), 4+ years (M.S.), or 5+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. strongly preferred.

• Strong foundation in mass spectrometry, with hands-on experience operating, troubleshooting, and optimizing LC-MS instrumentation.

• Experience developing and implementing mass spectrometry-based analytical, screening, and/or proteomics workflows.

• Demonstrated ability to apply mass spectrometry approaches to address biological questions and support drug discovery research.

• Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.

• Experience developing and optimizing sample preparation, chromatography, and mass spectrometry methods for biological applications.

• Strong data analysis and interpretation skills, with the ability to derive meaningful conclusions from complex mass spectrometry datasets.

• Ability to troubleshoot analytical challenges and contribute creative solutions to technical and scientific problems.

• Ability to collaborate effectively with scientists across biology, chemistry, and related disciplines to develop fit-for-purpose analytical approaches.

• Strong written, verbal, and presentation skills, with the ability to communicate scientific findings to multidisciplinary teams.

• Ability to work on-site in San Carlos, CA.

Preferred Qualifications:

• Experience with Orbitrap systems (Astral a plus) and/or Agilent Q-TOFs

• Knowledge of cancer pathways.

• Experience with ASMS and APMS workflows (in a drug discovery setting a plus)

Travel: None

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.