Postdoctoral Fellow (Nakamura) Extracellular Vesicles
Cincinnati Children's Hospital Medical Center
Cincinnati, OHFull-timeSeen 1w agoSeen in employer's feed 2 days ago
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Job overview
The Nakamura Laboratory is recruiting a postdoctoral fellow for an NIH-funded project investigating how obesity-associated metabolic stress changes liver-derived small extracellular vesicles and their RNA cargo, and how these vesicles affect macrophage inflammation and sepsis-related organ injury. The collaborative research spans Endocrinology and Critical Care Medicine and includes mechanistic and translational approaches using animal models, human-derived cells and biospecimens, vesicle profiling, and transcriptomic and bioinformatic analyses.
Skills & qualifications
Skills
Qualifications
Full job description
Primary Location Location T Department Endocrinology Shift Day (United States of America) Schedule Full time Weekly Hours 40 FTE 1 Employee Status Regular The Nakamura Laboratory is recruiting a highly motivated Postdoctoral Research Fellow to join a newly funded NIH R01 project examining how obesity-associated metabolic stress alters liver-derived small extracellular vesicles (sEVs) and their RNA cargo, and whether these vesicles reprogram macrophage inflammatory responses and worsen sepsis-related organ injury. This collaborative project spans Endocrinology and Critical Care Medicine and integrates mechanistic and translational research. Research focus and opportunities * Define nutrient-sensing and RNA-regulatory pathways that confer pro-inflammatory properties on liver-derived sEVs. * Identify sEV RNA cargo and macrophage sensing pathways that drive inflammatory reprogramming. * Determine how obesity-associated sEV signaling affects systemic inflammation and organ injury during sepsis. * Work across mouse models, hepatocyte-macrophage systems, human iPSC-derived hepatocytes and macrophages, human biospecimens, EV profiling, and transcriptomic/bioinformatic analyses. The ideal candidate * Has a recent PhD, MD, or equivalent and a strong peer-reviewed publication record. * Brings expertise in one or more of the following: immunology or innate immunity; inflammation or sepsis; EV/exRNA or RNA biology; metabolism; or mouse disease models. * Has experience with molecular and cellular biology, cell culture, flow cytometry, biochemistry, microscopy, and/or omics or computational analysis. * Is rigorous, independent, collaborative, and eager to develop new approaches. Applications for individual fellowships will be actively supported. MAJOR DUTIES AND RESPONSIBILITIES: * Develop the skills and knowledge (critical thinking and analysis of data, devising specific aims, long-term project planning and experimental design) to become an independent scientist * Design, execute, and record laboratory experiments, and analyze data, which may affect decisions regarding future patient care. * Research and improve current methods and evaluate innovative techniques. protocol and assay accuracy by conducting regular quality and reproducibility checks. Implement this knowledge in the Division/Department. Troubleshoot and correct erroneous results or problems with laboratory equipment. * Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis. * Present research at laboratory meetings, journal clubs, seminars, and meetings. Develop skills to critically review and discuss data being presented. * Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants. * Progressively increasing responsibilities with mentorship of research staff and fiscal administration * Maintain currency in field through continuing education, literature, and seminars. Be an active participant in the process through intellectual discussions with PI and other faculty, trainees and research staff. Solicit feedback on career trajectory from PI, mentoring committee and others who can provide coaching and insight. * Attend required Cincinnati Children's training sessions
How this job compares
Set against the 817 open Postdoctoral Researcher jobs on Olive Jobs, counted October 30, 2026.
- Pay
- This postingNot listed
- US median$70–80K/yr397 salary ranges
- Openings
- Olive Jobs lists 12 open Postdoctoral Researcher jobs in Ohio and 817 across the US. Under 1% of them nationwide are listed as remote or flexible.
- Hiring the most across the US
- Harvard University64 open
- Michigan State University(MSU)56 open
- Mount Sinai Health System49 open
- Experience
- Postdoctoral Researcher postings that state a minimum ask for 1 year of experience at the median; the middle half ask for 0 to 3 years (54 postings).
- Education
- 679 of the 817 open Postdoctoral Researcher jobs (83%) ask for a bachelor's degree or higher.
Counted across the open, public US postings on Olive Jobs on October 30, 2026. Pay medians are the middle values of the low ends and of the high ends of postings that list both ends of a range in the same cadence (a yearly salary or an hourly rate); a range's midpoint is halfway between its ends. Pay and experience figures resting on fewer than 20 postings are left out.
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