Associate Scientist – In Vivo Preclinical Pharmacology

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

We serve an extraordinary purpose. For more than 150 years, we have worked diligently to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world’s greatest health challenges.

At the Lilly Innovation Center in Boston, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our Genetic Medicine team in Boston shares a passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts’ exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.

The successful candidate will have a strong research track record in biology and be analytically minded, systematic, and embrace data-driven decision making. The scientist will collaborate with multidisciplinary teams across key Lilly therapeutic areas (with an emphasis on neuroscience and neurodegeneration) to perform experiments to aid development of RNA oligonucleotide drug candidates for the next generation of RNA therapies.

Key responsibilities include:

• Work with project team leads to design and plan in vivo experiments to support the preclinical characterization and evaluation of novel therapeutic molecules.

• Perform rodent handling and dosing, including but not limited to subcutaneous (SC), intravenous (IV), intraperitoneal (IP) and intrathecal (IT) injections.

• Perform small animal stereotaxic surgeries including but not limited to intracerebral (IC), intracisterna magna (ICM) and intracerebroventricular (ICV) injections in rodents.

• Perform tissue dissection, trimming and processing, collect bodily fluids (blood, cerebrospinal fluid).

• Process tissue samples for gene expression or protein endpoints (e.g RT-qPCR, Western blot, ELISA)

• Support technology development for improving the delivery of novel therapeutics to regions of interest in the central nervous system or other tissues.

• Assist in troubleshooting technical challenges and provide scientific and technical input to project teams

• Help design and complete experiments and perform data analysis

• Provide written and verbal communication of work in lab reports and team meetings

• Accurate recording of all practical work: completion of electronic notebook to Lilly procedure quality standards

• General laboratory assistance, including ordering and receiving lab supplies, preparation of reagents, and maintain laboratory equipment

• Ensure compliance with all health and safety regulations

• Passionate about contributing in the lab in a diverse and inclusive environment every day

Basic Qualifications:

• B.S. or M.S. in biology, biochemistry, pharmacology, or related scientific discipline

• 1+ years of experience working in the pharmaceutical industry, an academic laboratory, or similar settings

• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Additional Skills/Preferences :

• Experience in developing and working with in vivo models and assays to support drug discovery programs.

• Hands-on competencies in designing and implementing in vivo pharmacological experiments.

• Knowledge and understanding of drug delivery concepts is preferred.

• Strong expertise with in vivo tissue dissection and processing.

• Experience in gene expression assays (e.g. RT-qPCR) or protein assays (e.g. Western blot or ELISA)

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$72,000 - $189,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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