Scientist, Protein Biophysical Analysis

Job Description

Our large pharmaceutical client in Spring House, PA is seeking a Scientist for Protein Biophysical Analysis to join their growing Binding Group within Biologics Discovery. This group focuses on the development and application of preclinical assays in support of the discovery of therapeutic candidates. The scientist has responsibility for the application of technologies for biophysical and biochemical characterization and is responsible for implementing methods for affinity analysis.

Primary responsibilities include:

1. Kinetics, affinity and epitope binning analysis of antigens and antibodies using SPR, Carterra and KinExA.
2. Data analysis, Documentation, and reporting – ELNs, LIMS etc.,
3. Lab instrument maintenance – weekly and monthly maintenance, prepping buffer solutions and reagents.
4. Binding Lab specific supply maintenance – inventory and ordering.
5. Instrument and lab maintenance

Additional responsibilities may include:

1. Perform RT-IC analyses to assess the binding affinity of antibodies towards cells.
2. Support assay development and bioanalysis efforts, as needed.
3. Assist in drafting and executing peer reviewed posters, manuscripts, tech reports and patent filings.
4. Attend in-house seminars to support team goals as needed.
5. Present own work to members of department or external consultants as needed.

Skills and Requirements

-PhD/MS/BS with 1-5 years of experience in biochemistry, biophysics, immunology, molecular biology, analytical chemistry, or a related field. -2+ years of lab-based experience in Biophysical Binding analysis methods (e.g., Biacore, carterra, Other SPR methods (e.g Proteon), BLI (Octet), KinExA, Fluorescence anisotropy, RIA, or Flow cytometry affinity focused on affinity determination. -Solid understanding of protein biochemistry, binding affinity, thermodynamics, and antibody structure is strongly preferred. -Pharmaceutical experience with mass spectrometry characterization of antibodies -Experience analyzing biologics with chromatography methods (ex. HIC, SEC), including experience with common chromatography analysis platforms like Waters or Empower preferred. -Experience with lab automation and automated liquid handlers. -Experience performing RT-IC analyses to assess the binding affinity of antibodies towards cells.

We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal employment opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment without regard to race, color, ethnicity, religion, sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military or uniformed service member status, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to [email protected].