Cellular Molecular Pharmacology Scientist

Company Description

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins laboratories work with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. The Eurofins network of companies is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organisation services. It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations. It also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products. In over 30 years, Eurofins has grown from one laboratory in Nantes, France to 58,000 staff across a decentralised and entrepreneurial network of 900 laboratories in over 54 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products. In 2021, Eurofins generated total revenues of EUR 6.72 billion, and has been among the best performing stocks in Europe over the past 20 years.

Job Description

Role Overview We are seeking a highly motivated In Vivo Scientist to contribute to discovery research. This position will focus on HIV research, including virus production, characterization, and support of HIV discovery efforts. Key Responsibilities

• Lead the design, execution, optimization, and characterization of HIV production workflows. As well as inventory management.
• Conduct HIV discovery research using primary human cells (PBMCs, CD4+ T cells) and immortalized cell lines (THP-1, Jurkat, MT-4).
• Perform and analyze experiments utilizing multi-parameter flow cytometry (2 colors or more), RT-qPCR, PCR, ELISA, and MSD multiplex assays.
• Generate and characterize stable cell lines expressing proteins of interest.
• Support in vivo studies, including tissue collection and processing, and perform ex vivo viral RNA isolation from tissues and/or blood samples.
• Analyze and interpret experimental data, communicate findings, and contribute to project strategy and execution.

Qualifications

• Ph.D. in Biomedical Sciences, Microbiology, Immunology, Virology, or a related scientific discipline. Equivalent combination of a lesser degree and industry experience would also be acceptable.
• Demonstrated experience in HIV research and BSL-2 laboratory operations, with a strong HIV publication record preferred.
• Familiarity with HIV host-pathogen interactions.
• Expertise in viral propagation, concentration, and characterization techniques, including ultracentrifugation, viral titer determination, and neutralization assays.
• Hands-on experience with molecular biology techniques, including CRISPR gene editing, siRNA-mediated knockdown, transfection, site-directed mutagenesis, and Western blotting.
• Experience with in vivo mouse studies, including animal handling, tissue harvesting, and isolating viral RNA from ex vivo tissues and/or blood samples.
• Experience with ELISA.
• Proficiency with scientific data analysis and visualization software, including FlowJo, GraphPad Prism, and SnapGene or Geneious Prime.
• Strong problem-solving skills, attention to detail, and the ability to work effectively in a collaborative research environment.
• Authorization to work in the United States indefinitely without restrictions or sponsorship.

Nice to have

• Willingness to learn omics techniques, i.e. MSD multiplex assays, Nomics, Olink, 10X Genomics scRNAseq.

Additional Information

Position is Monday- Friday 8:00 am- 5:00 pm with overtime as needed. Candidates currently living within a commutable distance of West Point, PA are encouraged to apply. Excellent full time benefits including comprehensive medical coverage, dental, and vision options.

• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.