Protein Purification Scientist
Media, PAJobPosted 2mo ago
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Job overview
Insight Global is hiring a Protein Purification Scientist. The Protein Purification Scientist will support neurodegeneration drug discovery programs by purifying, quality controlling, and delivering human brain-derived Tau protein. This role requires strong hands-on expertise in protein biochemistry, purification from tissue samples, molecular and cell biology techniques, and assay execution. The scientist will work collaboratively, generate high-quality data, maintain accurate records, and communicate results effectively to project stakeholders.
Key focus areas include Execute Tau protein purification from human brain tissue using established protocols, Perform end-to-end purification workflows, including protein isolation, enrichment, quality control, and final product delivery, and Conduct analytical and functional assays, including HTRF, MSD, Western blotting, RT-qPCR, ELISA-based assays, and high-content imaging.
Important skills include Protein Biochemistry, Protein Purification From Tissue Samples, Molecular Biology Techniques, Cell Biology Techniques, Assay Execution, and Communication.
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Full job description
Job Description
We are seeking a highly motivated Protein Purification Scientist to support neurodegeneration drug discovery programs within the NeuroImmune group. The successful candidate will be responsible for the purification, quality control, and delivery of human brain-derived Tau protein to support research aligned with the neurodegeneration portfolio.
This role requires strong hands-on expertise in protein biochemistry, purification from tissue samples, molecular and cell biology techniques, and assay execution. The scientist will work closely within a collaborative team environment, generating high-quality data, maintaining accurate records, and communicating results effectively to project stakeholders.
Key Responsibilities
-Execute Tau protein purification from human brain tissue using established protocols.
-Perform end-to-end purification workflows, including protein isolation, enrichment, quality control, and final product delivery.
-Conduct analytical and functional assays, including:
-HTRF assays
-MSD assays
-Western blotting
-RT-qPCR
-ELISA-based assays
-High-content imaging
-Perform and maintain aseptic cell culture -procedures.
-Support iPSC-derived neuronal culture experiments as required.
-Analyze, interpret, and present experimental data to project teams and management.
-Maintain accurate and timely documentation in electronic laboratory notebooks (Signals ELN).
We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment regardless of their race, color, ethnicity, religion, sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military or uniformed service member status, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or recruiting process, please send a request to [email protected] learn more about how we collect, keep, and process your private information, please review Insight Global's Workforce Privacy Policy: https://insightglobal.com/workforce-privacy-policy/.
Skills and Requirements
-PhD in Biochemistry, Neuroscience, Molecular Biology, Cell Biology, or a related scientific discipline preferred
-Candidates with a Master's degree and relevant industry experience will also be considered
-Strong background in protein biochemistry
-Demonstrated hands-on protein purification experience, preferably from tissue-derived samples
Experience performing:
-Western blotting
-RT-qPCR
-Aseptic mammalian cell culture
-HTRF and/or MSD assays -Experience working with human brain tissue
-Experience purifying Tau protein or other aggregation-prone proteins associated with neurodegenerative diseases
-Hands-on experience with iPSC-derived neuronal cultures
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