Surface Plasmon Resonance Scientist

Job Description

We are seeking an an experienced biophysics scientist to support an AI-enabled antibody discovery initiative. The successful candidate will generate high-quality quantitative Surface Plasmon Resonance (SPR) datasets using the Carterra LSA XT high-throughput SPR platform to support development and training of in silico antibody design models. The role combines biophysical experimentation, kinetic data analysis, assay execution, data quality management, and cross-functional collaboration with computational and AI scientists.

Key Responsibilities: -Independently operate and maintain the Carterra LSA XT high-throughput SPR platform. -Execute affinity and kinetic characterization experiments for large numbers of antibody and protein designs. -Perform sensor chip preparation, protein immobilization, assay setup, and experimental execution. -Utilize validated protocols to support high-throughput screening activities. -Troubleshoot assay performance and optimize experimental conditions as needed

-Generate high-quality kinetic and affinity datasets, including: -KD (binding affinity) -kon (association rate) -koff (dissociation rate) -Analyze and validate experimental data to ensure accuracy and reproducibility. -Process and prepare datasets for downstream AI and machine learning applications. -Document all experimental activities, analyses, and outcomes within GSK Electronic Laboratory Notebook (ELN) systems.

Skills and Requirements

-Bachelors, Masters, or PHD with significant industry experience in Biochemistry, Biophysics, Protein Sciences, Molecular Biology, Chemical Biology, or related scientific discipline. -Hands-on experience with Surface Plasmon Resonance (SPR) technologies. -Biophysical characterization -Experience generating and interpreting protein-protein or antibody-antigen interaction data. -Strong understanding of binding kinetics and affinity measurements. Direct experience with Carterra LSA or Carterra LSA XT platforms.

We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal employment opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment without regard to race, color, ethnicity, religion, sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military or uniformed service member status, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to [email protected].