Principal Scientist - Genomics Cellular Biomarkers

Job Description

We have an exciting opportunity for a highly motivated, agile, and experienced scientist with lab level expertise in genomic technologies to join the Cellular Biomarkers Genomics group within the Biomarker and Bioanalytical Platform (BBP) department based in Collegeville, PA. Our group is responsible for development and use of genomics and proteogenomic biomarker assays in clinical studies.

You will generate data to support the understanding of disease heterogeneity, drug’s mechanism of action, and patient response to treatment at the molecular level through application of advanced genomic technologies, including Next Generation Sequencing (NGS), Olink Proximity Extension Assay (PEA), single cell analysis, qPCR, dd-PCR etc. You will conduct and oversee all aspects of the method development, troubleshooting, validation, and sample analysis for clinical studies requiring genomic and proteogenomic technologies’ endpoints including reagent selection/optimization, sample preparation, sample acquisition and data processing.

You will ensure all work is conducted in compliance with GCP regulations and follows the appropriate SOPs.

Key Responsibilities:

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following.

• Clinical Genomics/ Proteomics: You will generate data to support the understanding of disease heterogeneity, drug’s mechanism of action, and patient response to treatment at the molecular level through application of advanced genomic/ proteomic technologies, including Next Generation Sequencing (NGS), Olink PEA assays, qPCR, dd-PCR etc.
• Innovation: Evaluation of novel genomics/ proteomic techniques and technologies (i.e. single cell RNA-Seq, Olink PEA) to inform biomarker development and validation. Working in a matrix environment, identify and execute the validation of assays using human cells and tissues to enhance human translation and predictive value.
• Disease Biomarker Assay Development: You will conduct and oversee all aspects of the method development, troubleshooting, validation, and sample analysis for clinical studies requiring genomic technologies endpoints including reagent selection/optimization, sample preparation, sample acquisition and data processing. You will ensure that all work is conducted in compliance with GCLP regulations and follows the appropriate SOPs.
• Cross-functional Collaboration: Collaborate closely with cross-functional teams across GSK

Skills and Requirements

We are looking for professionals with these required skills to achieve our goals:

1. Ph.D. in a relevant scientific discipline (e.g., Biochemistry, Cell/Molecular Biology, Genetics, Genomics, proteomics or related field) or a B.S./M.S. degree with 1-2 years post-graduation experience in genomics, NGS, molecular or cellular biology, biomedical science, or related disciplines.
2. Scientific experience with current genomic analytical platforms (e.g., Single Cell RNA-Seq, RNA-Seq, Proteogenomic, qPCR, dd-PCR etc.) and basic understanding of genomics and proteomics data.
3. Experience supporting the design and interpretation of data from several of the following methods/assays: DNA and RNA sequencing technologies, Olink PEA Assays, single cell sequencing, and other emerging genomics/ proteogenomic technologies and commercial platforms. Experience in designing, troubleshooting, and implementing Olink PEA assays, single cell RNA-Seq applications (e.g., 10x Genomics, BD Rhapsody, Parse), or similar high content techniques.

We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal employment opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment without regard to race, color, ethnicity, religion, sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military or uniformed service member status, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to [email protected].