Senior Research Associate (SRA), Cell Line Engineering

South San Francisco, CA

The Company

Link Cell Therapies is developing a best-in-class logic-gate technology to spur a new generation of cell therapies for patients with solid tumors. Link’s “AND” gates require two cancer-associated targets for a CAR T cell to attack cancer cells, thereby providing specificity for killing of tumor cells while sparing healthy tissue. Combined with additional technologies under development, Link will advance a suite of exciting internal therapeutic programs while exploring opportunities for value creation with strategic partners.

Job Description

Link Cell Therapies is looking for a highly motivated SRA to join our Cell Therapy team and support cell line engineering efforts. Reporting to the Molecular Biology & Cell Line Development Lead, the successful applicant will collaborate effectively with other scientists and be responsible for developing, establishing, and characterizing cell lines to enable the advancement of our company’s pipeline programs. This is an opportunity to join an exciting new company during the discovery phase and to follow our programs throughout research pipeline advancement and into clinical studies.

Responsibilities

• Generate engineered cell lines via gene-editing strategies, including but not limited to lentiviral gene delivery and CRISPR gene knockouts
• Own end-to-end cell line engineering workflows and troubleshoot cell line engineering processes
• Contribute to the development of strategies for efficient cell line gene-editing, and integrate new methodologies and techniques into the workflow
• Maintain, propagate and cryopreserve cell lines
• Collaborate and communicate with other scientists to align on key deliverables
• Ensure accurate and organized record-keeping of cell line database, batch records and electronic laboratory notebook

Preferred Qualifications

• Experience: B.S. with 3-5 years or M.S. with 1-3 years of relevant industry experience
• Demonstrated proficiency in suspension and adherent aseptic cell culture and BSL-2 biosafety requirements
• Experience with cell banking, cell bank inventory management, and quality control methods
• Hands-on experience with cell line editing techniques, including transfection, transduction, and selection
• Familiarity with single cell cloning isolation and expansion workflows
• Working knowledge of CRISPR design principles, CRISPR electroporation, and knockout validation
• Experience and knowledge on multi-color flow cytometry, including staining, analysis and fluorescence-activated cell sorting
• Self-motivator with a willingness to learn and adopt new methodologies and techniques
• Excellent organizational skills, record-keeping and attention to detail

This is a hands-on, lab-based and on-site position based in South San Francisco, CA.

The salary range for this position is $109,000-125,000 USD annually. We encourage candidates of all levels to apply as there is sometimes flexibility on job level and responsibilities. Compensation will be based on a variety of factors, including experience and qualifications.

In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.