Purification Scientist (Chemistry)

Job Description

Our large pharmaceutical client in La Jolla, CA is seeking a highly motivated BS- or MS-level chemist with small molecule purification skills to advance drug discovery programs toward the clinic. In this laboratory-based position, the successful candidate will perform high throughput purification of small molecule pharmaceuticals synthesized by medicinal chemists. This includes the purification of compounds from focused chemical libraries or singleton samples with mass-directed Super Fluid Chromatography (SFC) or High Performance Liquid Chromatography (HPLC). She/he will maintain close interactions with scientists from Discovery Chemistry, Discovery Process Chemistry and Parallel Medicinal Chemistry teams to expedite the compound design-synthesis-test iterations. Strong people skills and the ability to thrive in a team and goal driven environment are key attributes.

Additional Responsibilities: -Conduct daily system suitability check on SFC-MS and LC-MS instrumentation -Maintain instruments in good working condition and perform troubleshooting analysis and maintenance as required -Assist with preliminary screening experiments prior to sample purification and post purification sample downstream handling -Assist with chiral characterization of small molecules -Conduct ad hoc large scale (grams) purification work for small molecules -Support lab operations and maintain general lab orderliness -Assist in the maintenance of a safe working environment and operate in a safe manner -Other duties and assignments as needed to support the lab operations

Skills and Requirements

-A minimum of a bachelor’s degree in Analytical, Synthetic, Organic, Medicinal Chemistry or related Chemistry degree -Minimum of 2 years small molecule purification and mass spectrometry experience -HPLC or SFC chromatography experience -Knowledge of LCMS and molecular properties -Knowledge of NMR -Experience with Waters/Agilent equipment -TECAN or other liquid handlers for lab automation

We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal employment opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment without regard to race, color, ethnicity, religion, sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military or uniformed service member status, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to [email protected].