Lentiviral Vector Downstream Process Development Scientist

Job Description

Our large pharmaceutical client in Spring House, PA is seeking a Downstream Process Development Scientist to support the small-scale lentiviral vector downstream team on platform process optimization, characterization, new processes development, investigations, and technical transfer. Responsibilities include:

• Conduct small scale lentiviral vector production process development using material from mammalian cell culture. Purification techniques will include depth filtration, affinity and/or Ion exchange (IEX) chromatography, and tangential flow filtration (TFF), sterile filtration etc
• Management of experimental samples, including aliquoting, storage, and shipment as needed.
• Analyze data post run and present analysis.
• Maintain record of analytical data into data sheets and/or electronic lab notebooks.
• Ensure compliance with all company policies and procedures, and all relevant safety and quality standards.
• Effectively communicate with internal and external teams.
• Identify gaps and root causes of issues and think out of the box to develop a solution.

Skills and Requirements

• 2+ years of hands-on experience as a lab-based Scientist supporting downstream work including filtration of material, protein chromatography, and TFF (Tangential Flow Filtration)
• Protein chromatography experience – bind/elute, ion exchange, or size exclusion
• Lentiviral downstream process development experience
• Previous experience with large scale filtration and purification systems
• Hands on experience with Cytiva AKTA
• Experience with modeling software tools a plus.

We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal employment opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment without regard to race, color, ethnicity, religion, sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military or uniformed service member status, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to [email protected].