Clinical Bioinformatics Scientist II

Clinical Bioinformatics Scientist II

Locations:

Los Angeles, California

Job Category:

Professional

Position Type:

Full-Time

Shift:

Days

Job Description

Join a team that's shaping the future of pediatric care. Children’s Hospital Los Angeles is consistently ranked among the top 10 children's hospitals in the nation, delivering world-class care through more than 350 specialized programs and services. Here, world-class experts in medicine, research, and education work together to deliver family-centered care to more than 155,000 patients each year. At CHLA, your work will help build brighter tomorrows for the children and families we serve.

Overview

Schedule: Full-Time, Exempt. Standard Monday-Friday business hours.

Hybrid; Flexible: 3 days/week onsite

Purpose Statement/Position Summary: The Clinical Bioinformatics Scientist II will perform analysis of next-generation sequencing (NGS) data or high throughput array data, primarily for clinical diagnosis purposes. Will analyze and interpret whole-exome sequencing, targeted re-sequencing, whole-genome genotyping, and whole-genome sequencing data in order to identify genetic variants that are causal to or associated with genetic disorders and childhood cancers. The successful candidate will not only be able to use established clinical workflows and software packages, but also be able to develop customized pipelines, databases and novel methodologies as needed. The Clinical Bioinformatics Scientist II is expected to participate in various clinical and research projects that will lead to novel clinical insights and publications. He/she also provides research support to investigators and assists in training investigators and new users to use bioinformatics applications and databases.

The Clinical Bioinformatics Scientist II must be able to perform all responsibilities of the Clinical Bioinformatics Scientist I job description. All responsibilities listed in this description are additional.

Minimum Qualifications/Work Experience:

• Demonstrated ability to manage multiple projects and overlapping deadlines and dependencies.

• Excellent communication skills, both written and verbal is required.

• Familiarity with various publicly available databases such as HGMD, ClinVar, TCGA, ICGC, Ensembl, Refseq, UCSC, 1000 Genome and ExAC.

• Capable of designing and executing medium scale projects and programs.

• Demonstrated ability to implement and understand complex algorithms.

• Ability to develop and implement methods/algorithms and integrate tools and software resources for data analysis.

• Intermediate experience with data/statistical analysis.

• Experience with genomic or proteomic data analysis methods required.

• Demonstrated ability to organize and perform analysis of large-scale complex data sets including statistical tests and quality analysis.

Preferred experience:

• Experience developing AI/ML and large language model (LLM) applications, including NLP for analyzing, extracting, and structuring information from unstructured documents.

• Experience with full-stack application development, including user interfaces, backend services, APIs, and databases.

• Experience with modern AI approaches such as RAG, semantic search, vector databases, and/or agentic AI workflows.

• Experience developing secure, reliable, and scalable applications using structured and unstructured data

Education/Licensure/Certification:

Bachelor’s degree in bioinformatics or related field with 2+ years of related work experience.

Advanced degree preferred.

Pay Scale Information

USD $100,630.00 - USD $134,160.00

CHLA values the contribution each Team Member brings to our organization. Final determination of a successful candidate’s starting pay will vary based on a number of factors, including, but not limited to, education and experience within the job or the industry. The pay scale listed for this position is generally for candidates who meet the specified qualifications and requirements listed on this specific job description. Additional pay may be determined for those candidates who exceed these specified qualifications and requirements. We provide a competitive compensation package that recognizes your experience, credentials, and education alongside a robust benefits program to meet your needs.

About Us

CHLA is a leader in pediatric and adolescent health, in our community, across the nation, and around the world . As a premier Magnet®-recognized teaching hospital, CHLA offers an environment rooted in learning, collaboration, and compassionate care. . We are home to groundbreaking research, clinical innovation, and a culture that supports personal and professional growth.

Since 1932, CHLA has been affiliated with the Keck School of Medicine of the University of Southern California. Through this partnership and our own enduring mission, we remain committed to creating hope and building healthier futures.

CHLA is an Equal Opportunity Employer

At Children’s Hospital Los Angeles, our work matters. And so do each and every one of our valued team members. We consider qualified applicants for all positions without regard to race, color, religion, creed, national origin, sex, gender identity, age, physical or mental disability, sexual orientation, marital status, veteran or military status, genetic information or any other legally protected basis under federal, state or local laws, regulations or ordinances. We will also consider for employment qualified applicants with criminal history, in a manner consistent with the requirements of state and local laws, including the LA City Fair Chance Ordinance and SF Fair Chance Ordinance.

Qualified Applicants with disabilities are entitled to reasonable accommodation under the California Fair Employment and Housing Act and the Americans with Disabilities Act. Please contact CHLA Human Resources if you need assistance completing the application process.

Our various experiences, perspectives and backgrounds allow us to better serve our patients and create a strong community at CHLA.