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AI Biologist - Biologics Drug Discovery

LatchBio

San Francisco, CARemoteFull-time$120–180K/yrPosted 2mo agoVerified open 1w ago
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At a glance

Compensation
$120–180K/yr
Location
San Francisco, CARemote
Schedule
Full-time
Work Authorization
US work authorization required

Job overview

LatchBio is hiring a Bioinformatics Engineer - Biologics Drug Discovery. LatchBio seeks a Bioinformatics Engineer for its Biologics Drug Discovery team to advance AI-driven analysis of therapeutic datasets. The role involves creating benchmark datasets, measuring agent performance, and collaborating with software engineers and biologists to enhance decision‑making in antibody and protein discovery.

Key focus areas include Contribute to technical approach for evaluating AI agents on biologics datasets, Build ground‑truth benchmark datasets from real antibody and protein programs, and Define metrics to assess agent capability in therapeutic decision‑making.

Successful candidates bring 2+ Years Hands-On Biologics Discovery Or Development Experience and Work Authorization: OPT Visa Holders Only. Important skills include Variant Ranking, Enrichment Analysis, Advancement Prioritization, Interpreting Binding Kinetics, Interpreting Biophysical Stability Data, and Interpreting Cell-Based Potency Assays. Preferred (not required): Immunogenicity Risk Assessment, Potency Assay Design, ELISA, and Biochemical Assays.

Skills & qualifications

RequiredNice to have

Skills

Variant RankingEnrichment AnalysisAdvancement PrioritizationInterpreting Binding KineticsInterpreting Biophysical Stability DataInterpreting Cell-Based Potency AssaysPythonRAntibody OptimizationCDR EngineeringVH/VL PairingVariant ScreeningProtein StructureAlphaFoldCryo-EMDockingHigh-Throughput Antibody/Binding ScreensPK/PD Modeling for BiologicsTarget OccupancyHalf-LifeClearanceBioprocess/Manufacturability ConstraintsImmunogenicity Risk AssessmentPotency Assay DesignELISABiochemical AssaysCMC/GMP-Adjacent KnowledgeManagement Skills

Qualifications

2+ Years Hands-on Biologics Discovery or Development ExperienceWork Authorization: OPT Visa Holders Only

Full job description

AI Biologist - Biologics Drug Discovery

As molecular data generation and frontier model intelligence grows, new approaches to data analysis are needed across the biotech industry. Latch is building intelligent, high-performance agents for biological data analysis, empowering over 5,000 scientists across 150+ R&D labs to handle data from instrument-to-insights.

We're seeking a Bioinformatics Engineer to join our Biologics Drug Discovery team, working at the frontier of what artificial intelligence can achieve in biology.

About the Role

You will contribute to our technical approach for evaluating how AI agents reason through complex biologics therapeutics datasets. Working with software engineers and biologists, you'll build ground-truth benchmark datasets - drawn from real antibody and protein discovery programs - that rigorously test whether agents can perform the critical decision-making steps that human scientists execute.

Your hands-on expertise in variant ranking, enrichment analysis, and advancement prioritization will define how we measure agent capability in therapeutic discovery.

Requirements

  • 2+ years hands-on experience with biologics discovery or development (antibody engineering, protein engineering, or cell/molecular biology-driven target validation)

  • Experience interpreting binding kinetics (SPR/BLI), biophysical stability data, and/or cell-based potency assays

  • Proficiency in Python and/or R for data analysis & visualization

  • Familiarity with at least one of:

  • Antibody optimization (CDR engineering, VH/VL pairing, variant screening)

  • Protein structure (AlphaFold, cryo-EM, docking)

  • High-throughput antibody/binding screens

  • PK/PD modeling for biologics (target occupancy, half-life, clearance) -

  • Bioprocess/manufacturability constraints

Nice-to-Have

  • Experience with immunogenicity risk assessment

  • Hands-on work with potency assay design (ELISA, cell-based, biochemical)

  • CMC/GMP-adjacent knowledge

Culture @ Latch

How we work. Genuinely flexible schedules - we just ask that you communicate when you're coming in later than usual. We care most about hard work and output. We're respectfully opinionated, it will always be us against problems, not each other. Optimize for each other's time and bring solutions, not just problems. You'll join a bench suited to your expertise, but we value cross-domain learning and interoperability across teams.

The office & perks. Waterfront office near Oracle Park, 2x free daily meals, unlimited snacks, company outings most months, and team offsites. Plus a vibrant community: cycling, soccer, figure skating, boxing, run clubs, reading clubs, martial arts, music, game nights.

Compensation & Logistics

  • 1099 (or W8-BEN) contract, 40 hrs/week, no end date

  • Fully performance-based pay: $120K–$180K, uncapped upside. 2x quota = 2x pay.

  • 2-4 week paid ramp—full OTE from day one

  • Remote (globally), hybrid, or onsite in SF (onsite preferred)

  • Work authorization: OPT visa holders only (not STEM Extension)

  • Onsite perks: 2x free meals/day, waterfront office (China Basin), monthly parking (based on availability)

  • Candidates with all of the above qualifications + proven management skills will be eligible for more senior positions

Interview Process

Timeline: We move fast: 8–12 days from submission to offer.

  • Intro Screen - Technical Recruiter

  • Take-Home Project - HackerRank

  • Technical Interview - Member of Technical Staff

  • Culture Interview - C-Suite (If applicable)

  • Offer

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